nothing sadder than a withered heart (idiom attributed to Confucius by Zhuangzi 莊子|庄子[Zhuang1 zi3]) / no greater sorrow than a heart that never rejoices / the worst sorrow is not as bad as an uncaring heart / nothing is more wretched than apathy
(of time or place) in; at; on / (indicating any indirect relation) to; toward; vis-à-vis; with regard to; for / (indicating a source) from; out of / (used in comparison) than / (used in the passive voice) by