利害攸关

to be of vital interest

sharp / favorable / advantage / benefit / profit / interest / to do good to / to benefit

pros and cons / advantages and disadvantages / gains and losses

terrible / formidable / serious / devastating / tough / capable / sharp / severe / fierce

to do harm to / to cause trouble to / harm / evil / calamity

distant, far / adverbial prefix

of great concern

mountain pass / to close; to shut; to turn off / to confine; to lock (sb) up; to shut (sb in a room, a bird in a cage etc) / to concern; to involve